A new subgroup of immunoglobulin heavy chain variable region genes for the assessment of clonality in feline B-cell lymphomas.

@article{Henrich2009ANS,
  title={A new subgroup of immunoglobulin heavy chain variable region genes for the assessment of clonality in feline B-cell lymphomas.},
  author={Manfred Henrich and Werner Hecht and Alexander Th A Weiss and Manfred Reinacher},
  journal={Veterinary immunology and immunopathology},
  year={2009},
  volume={130 1-2},
  pages={59-69}
}
In human medicine, PCR-amplification of the complementarity determining region 3 of the immunoglobulin heavy chain genes followed by polyacrylamide gel electrophoresis (PAGE) is an accepted method to assess clonality in B-cell lymphomas and thereby facilitates the differentiation of neoplasias from benign hyperplasias or reactive infiltrates. To generate a basis for the development of a PCR-based assay for the assessment of clonality in feline B-cell lymphomas we analyzed 28 transcripts (cDNA… CONTINUE READING