A new strategy for the synthesis of taurine derivatives using the 'safety-catch' principle for the protection of sulfonic acids.

@article{Seeberger2007ANS,
  title={A new strategy for the synthesis of taurine derivatives using the 'safety-catch' principle for the protection of sulfonic acids.},
  author={Sonja Seeberger and R. Griffin and I. Hardcastle and B. Golding},
  journal={Organic \& biomolecular chemistry},
  year={2007},
  volume={5 1},
  pages={
          132-8
        }
}
The safety-catch principle has been applied for the development of a new method for protecting sulfonic acids. 2,2-Dimethylsuccinic acid was reduced to 2,2-dimethylbutane-1,4-diol, which was selectively silylated to give 4-(tert-butyldiphenylsilanyloxy)-2,2-dimethylbutan-1-ol. Reaction of the latter compound with 2-chloroethanesulfonyl chloride in the presence of triethylamine afforded 4-(tert-butyldiphenylsilyloxy)-2,2-dimethylbutyl ethenesulfonate directly. The ethenesulfonate underwent… Expand
11 Citations
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