A new strategy for the discovery of epimedium metabolites using high-performance liquid chromatography with high resolution mass spectrometry.

@article{Jin2013ANS,
  title={A new strategy for the discovery of epimedium metabolites using high-performance liquid chromatography with high resolution mass spectrometry.},
  author={Ying Jin and Cai-Sheng Wu and Jin-lan Zhang and Ying-Fei Li},
  journal={Analytica chimica acta},
  year={2013},
  volume={768},
  pages={111-7}
}
In this paper, a new strategy of drug metabolite discovery and identification was established using high-performance liquid chromatography with high resolution mass spectrometry (HPLC-HRMS) and a mass spectral trees similarity filter (MTSF) technique. The MTSF technique was developed as a means to rapidly discover comprehensive metabolites from multiple active components in a complicated biological matrix. Using full-scan mass spectra as the stem and data-dependent subsequent stage mass spectra… CONTINUE READING