A new story ARC for α-granule formation.

Congenital defects in platelet granule formation, although unusual, have been instrumental in providing a glimpse into the mechanisms of granule biogenesis. In this issue of Blood, Bem et al now generate and characterize a murine model of arthrogryposis, renal dysfunction, and cholestasis (ARC) syndrome with an inducible deficiency in VPS33B that sheds new… CONTINUE READING