A new statistical test for linkage heterogeneity.

@article{Risch1988ANS,
  title={A new statistical test for linkage heterogeneity.},
  author={Neil J. Risch},
  journal={American journal of human genetics},
  year={1988},
  volume={42 2},
  pages={353-64}
}
  • Neil J. Risch
  • Published 1988 in American journal of human genetics
A new, statistical test for linkage heterogeneity is described. It is a likelihood-ratio test based on a beta distribution for the prior distribution of the recombination fraction among families (or individuals). The null distribution for this statistic (called the B-test) is derived under a broad range of circumstances. Two other heterogeneity test statistics--the admixture test or A-test first described by Smith and Morton's test (here referred to as the K-test)--are also examined. The… CONTINUE READING

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