A new short-term mouse model of chronic obstructive pulmonary disease identifies a role for mast cell tryptase in pathogenesis.

@article{Beckett2013ANS,
  title={A new short-term mouse model of chronic obstructive pulmonary disease identifies a role for mast cell tryptase in pathogenesis.},
  author={Emma Louise Beckett and Richard L. Stevens and Andrew Gregory Jarnicki and Richard Yong Kim and Irwan Hanish and Nicole G Hansbro and Andrew Deane and Simon Keely and Jay Christopher Horvat and Ming Yang and Brian Gregory George Oliver and Nico Van Rooijen and Mark D. Inman and Roberto Adachi and Roy J. Soberman and Sahar Hamadi and Peter A B Wark and Paul S Foster and Philip M Hansbro},
  journal={The Journal of allergy and clinical immunology},
  year={2013},
  volume={131 3},
  pages={752-62}
}
BACKGROUND Cigarette smoke-induced chronic obstructive pulmonary disease (COPD) is a life-threatening inflammatory disorder of the lung. The development of effective therapies for COPD has been hampered by the lack of an animal model that mimics the human disease in a short timeframe. OBJECTIVES We sought to create an early-onset mouse model of cigarette smoke-induced COPD that develops the hallmark features of the human condition in a short time-frame. We also sought to use this model to… CONTINUE READING
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