A new semiempirical codon substitution model based on principal component analysis of mammalian sequences.

@article{Zoller2012ANS,
  title={A new semiempirical codon substitution model based on principal component analysis of mammalian sequences.},
  author={Stefan Zoller and Adrian Schneider},
  journal={Molecular biology and evolution},
  year={2012},
  volume={29 1},
  pages={271-7}
}
Codon substitution models have traditionally been parametric Markov models, but recently, empirical and semiempirical models also have been proposed. Parametric codon models are typically based on 61×61 rate matrices that are derived from a small number of parameters. These parameters are rooted in experience and theoretical considerations and generally show good performance but are still relatively arbitrary. We have previously used principal component analysis (PCA) on data obtained from… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.

Explore Further: Topics Discussed in This Paper

Citations

Publications citing this paper.

References

Publications referenced by this paper.
Showing 1-10 of 18 references

Model selection and multimodel inference: a practical information-theoretic approach

K Burnham, D. Anderson
New York: Springer. • 2002
View 16 Excerpts
Highly Influenced

A codon-based model of nucleotide substitution for protein-coding DNA sequences.

Molecular biology and evolution • 1994
View 7 Excerpts
Highly Influenced

Markovian codon models of evolution for phylogeny inference [master’s thesis

Zanetti MS.
ETH Zurich. • 2010

Similar Papers

Loading similar papers…