A new secreted protein that binds to Wnt proteins and inhibits their activites

@article{Hsieh1999ANS,
  title={A new secreted protein that binds to Wnt proteins and inhibits their activites},
  author={J. Hsieh and Laurent Kodjabachian and Martha L. Rebbert and Amir Rattner and Philip M. Smallwood and Cynthia Harryman Samos and Roeland Nusse and Igor B Dawid and Jeremy Nathans},
  journal={Nature},
  year={1999},
  volume={398},
  pages={431-436}
}
The Wnt proteins constitute a large family of extracellular signalling molecules that are found throughout the animal kingdom and are important for a wide variety of normal and pathological developmental processes,. Here we describe Wnt-inhibitory factor-1 (WIF-1), a secreted protein that binds to Wnt proteins and inhibits their activities. WIF-1 is present in fish, amphibia and mammals, and is expressed during Xenopus and zebrafish development in a complex pattern that includes paraxial… CONTINUE READING
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