A new safety index based on intrapulse monitoring of ultra-harmonic cavitation during ultrasound-induced blood-brain barrier opening procedures

  title={A new safety index based on intrapulse monitoring of ultra-harmonic cavitation during ultrasound-induced blood-brain barrier opening procedures},
  author={A. Novell and H. Kamimura and A. Cafarelli and M. Gerstenmayer and J. Flament and J. Valette and P. Agou and A. Conti and E. Selingue and R. Aron Badin and P. Hantraye and B. Larrat},
  journal={Scientific Reports},
Ultrasound-induced blood-brain barrier (BBB) opening using microbubbles is a promising technique for local delivery of therapeutic molecules into the brain. The real-time control of the ultrasound dose delivered through the skull is necessary as the range of pressure for efficient and safe BBB opening is very narrow. Passive cavitation detection (PCD) is a method proposed to monitor the microbubble activity during ultrasound exposure. However, there is still no consensus on a reliable safety… Expand
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