A new role of CTLA-4 on B cells in thymus-dependent immune responses in vivo.

@article{Quandt2007ANR,
  title={A new role of CTLA-4 on B cells in thymus-dependent immune responses in vivo.},
  author={Dagmar Quandt and H. Richard Hoff and Marion Rudolph and Simon Fillatreau and Monika C Brunner-Weinzierl},
  journal={Journal of immunology},
  year={2007},
  volume={179 11},
  pages={
          7316-24
        }
}
The expression of CTLA-4 (CD152) on the cell surface of B cells and its consequences for the humoral immune response in vivo are unknown. We investigated the expression of CTLA-4 mRNA and protein in B cells in T cell-independent or -dependent ways. B cells in the presence of Ag-stimulated Th2 cells expressed mRNA of CTLA-4 and up-regulated intracellular CTLA-4 protein. Using a liposome-enhanced staining technique, we show for the first time, that surface CTLA-4 protein is expressed by 11-15% of… CONTINUE READING
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