A new role for the von Hippel-Lindau tumor suppressor protein: stimulation of mitochondrial oxidative phosphorylation complex biogenesis.

@article{Hervouet2005ANR,
  title={A new role for the von Hippel-Lindau tumor suppressor protein: stimulation of mitochondrial oxidative phosphorylation complex biogenesis.},
  author={Eric Hervouet and Jocelyne Demont and Petr Pecina and Alena Vojt{\'i}skov{\'a} and Josef Hou{\vs}těk and H{\'e}l{\`e}ne Simonnet and Catherine Godinot},
  journal={Carcinogenesis},
  year={2005},
  volume={26 3},
  pages={531-9}
}
Although mitochondrial deficiency in cancer has been described by Warburg, many years ago, the mechanisms underlying this impairment remain essentially unknown. Many types of cancer cells are concerned and, in particular, clear cell renal carcinoma (CCRC). In this cancer, the tumor suppressor gene, VHL (von Hippel-Lindau factor) is invalidated. Previous… CONTINUE READING