A new role for the A2b adenosine receptor in regulating platelet function.

@article{Yang2010ANR,
  title={A new role for the A2b adenosine receptor in regulating platelet function.},
  author={Dan Yang and Haiping Chen and Milka Koupenova and Shannon Holly Carroll and Alexia Eliades and Jonathan E. Freedman and Paul A. Toselli and Katya Ravid},
  journal={Journal of thrombosis and haemostasis : JTH},
  year={2010},
  volume={8 4},
  pages={
          817-27
        }
}
BACKGROUND Activation of platelets is a critical component of atherothrombosis and plays a central role in the progression of unstable cardiovascular syndromes. Adenosine, acting through adenosine receptors, increases intracellular cAMP levels and inhibits platelet aggregation. The A2a adenosine receptor has already been recognized as a mediator of adenosine-dependent effects on platelet aggregation, and here we present a new role for the A2b adenosine receptor (A2bAR) in this process… CONTINUE READING
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