A new role for tamoxifen in oestrogen receptor-negative breast cancer when it is combined with epigallocatechin gallate

@article{Scandlyn2008ANR,
  title={A new role for tamoxifen in oestrogen receptor-negative breast cancer when it is combined with epigallocatechin gallate},
  author={M. Scandlyn and E. C. Stuart and T. J. Somers-Edgar and A. Menzies and R. Rosengren},
  journal={British Journal of Cancer},
  year={2008},
  volume={99},
  pages={1056 - 1063}
}
We have previously shown that tamoxifen+epigallocatechin gallate (EGCG) is synergistically cytotoxic towards oestrogen receptor (ER)-negative breast cancer cells. To determine if this response would correlate with significant tumour suppression in vivo, athymic nude female mice were implanted with MDA-MB-231 cells and treated with tamoxifen, EGCG, EGCG+tamoxifen, or vehicle control for 10 weeks. Tumour volume in EGCG- (25 mg kg−1)+tamoxifen (75 μg kg−1)-treated mice decreased by 71% as compared… Expand
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References

SHOWING 1-10 OF 46 REFERENCES
Tamoxifen and epigallocatechin gallate are synergistically cytotoxic to MDA-MB-231 human breast cancer cells
Tamoxifen induces oxidative stress and apoptosis in oestrogen receptor-negative human cancer cell lines
Synergistic inhibitory effects of genistein and tamoxifen on human dysplastic and malignant epithelial breast cells in vitro.
The combination of green tea and tamoxifen is effective against breast cancer.
Potential mechanisms for the synergistic cytotoxicity elicited by 4-hydroxytamoxifen and epigallocatechin gallate in MDA-MB-231 cells.
Synergistic cytotoxic effects of tamoxifen and black cohosh on MCF-7 and MDA-MB-231 human breast cancer cells: an in vitro study.
...
1
2
3
4
5
...