A new role for P-selectin in shear-induced platelet aggregation.

@article{Merten2000ANR,
  title={A new role for P-selectin in shear-induced platelet aggregation.},
  author={Michael Merten and Theodore Chow and J. David Hellums and Padma Thiagarajan},
  journal={Circulation},
  year={2000},
  volume={102 17},
  pages={2045-50}
}
BACKGROUND P-selectin, expressed on platelets on activation, mediates rolling of platelets on endothelial cells, but its role in shear-induced platelet aggregation is not known. METHODS AND RESULTS Platelets were exposed to either a single pulse (30 seconds) or 3 pulses (10 seconds) of high shear stress (150 to 200 dynes/cm(2)) each followed by low shear stress (10 dynes/cm(2)) for 4.5 minutes or 90 seconds, respectively, at 37 degrees C to resemble more closely in vivo conditions such as… CONTINUE READING
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