A new role for ATM: regulating mitochondrial function and mitophagy.

@article{ValentinVega2012ANR,
  title={A new role for ATM: regulating mitochondrial function and mitophagy.},
  author={Yasmine A. Valentin-Vega and Michael B. Kastan},
  journal={Autophagy},
  year={2012},
  volume={8 5},
  pages={
          840-1
        }
}
The various pathologies in ataxia telangiectasia (A-T) patients including T-cell lymphomagenesis have been attributed to defects in the DNA damage response pathway because ATM, the gene mutated in this disease, is a key mediator of this process. Analysis of Atm-deficient thymocytes in mice reveals that the absence of this gene results in altered mitochondrial homeostasis, a phenomenon that appears to result from abnormal mitophagy engagement. Interestingly, allelic loss of the autophagic gene… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 23 CITATIONS

Similar Papers

Loading similar papers…