A new role for 5-methoxytryptophol on bone cells function in vitro.

@article{Satue2015ANR,
  title={A new role for 5-methoxytryptophol on bone cells function in vitro.},
  author={Maria Satue and Joana Maria Ramis and Maria del Mar Arriero and Marta Monjo},
  journal={Journal of cellular biochemistry},
  year={2015},
  volume={116 4},
  pages={551-8}
}
The present study investigates the direct action of 5-methoxytryptophol (5-MTX) in both MC3T3-E1 and RAW264.7 cells and compares it with melatonin (MEL), another 5-methoxyindol known to play a significant role on bone metabolism. We first screened increasing doses of both 5-MTX and MEL to determine their effect on metabolic activity and viability of preosteoblastic MC3T3-E1 cells. The optimal dose was used to determine its effect on differentiation of MC3T3-E1 cells and preosteoclastic RAW264.7… CONTINUE READING