A new road to neuroinflammation in Parkinson's disease?

@article{Fuxe2008ANR,
  title={A new road to neuroinflammation in Parkinson's disease?},
  author={Kjell Fuxe and Alexander O. Tarakanov and Larisa B. Goncharova and Luigi Francesco Agnati},
  journal={Brain Research Reviews},
  year={2008},
  volume={58},
  pages={453-458}
}
Common architecture of cytokine receptors and G-protein coupled receptors (GPCRs) may underlie pathological receptor heteromer formation and signaling. Here, we clarify how chemokines and cytokines can participate in pathogenic processes of Parkinson's disease, especially in dopaminergic neurons of substantia nigra. Possible common architecture of GPCRs and cytokine receptors suggests that they may act as molecular switches similar to the prototypical innate immune receptors: Toll-like… CONTINUE READING

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