A new risk variant for multiple sclerosis at the immunoglobulin heavy chain locus associates with intrathecal IgG, IgM index and oligoclonal bands.

@article{DelgadoGarca2015ANR,
  title={A new risk variant for multiple sclerosis at the immunoglobulin heavy chain locus associates with intrathecal IgG, IgM index and oligoclonal bands.},
  author={Mercedes Delgado-Garc{\'i}a and Fuencisla Matesanz and Antonio Alcina and Mar{\'i}a Fedetz and M. I. Garc{\'i}a-s{\'a}nchez and Juan Lu{\'i}s Ruiz-Pe{\~n}a and {\'O}scar Fern{\'a}ndez and Mar{\'i}a Jes{\'u}s Pinto Medel and Laura Alvarado Leyva and Carmen Mar{\'i}a Zavala Arnal and Concepci{\'o}n Mª Delgado and Jos{\'e} Antonio L{\'o}pez Guerrero and Antonio Gonz{\'a}lez-P{\'e}rez and Mar{\'i}a Eugenia S{\'a}ez and Luisa M Villar and Jos{\'e} Carlos {\'A}lvarez-Cerme{\~n}o and C M Manuel Pic{\'o}n and Rafael Arroyo and Jezabel Varad{\'e} and Elena Urcelay and Guillermo Izquierdo and Miguel Lucas},
  journal={Multiple sclerosis},
  year={2015},
  volume={21 9},
  pages={
          1104-11
        }
}
BACKGROUND Recent findings have shown a correlation between the intrathecal IgG index and variants at the immunoglobulin heavy chain (IGHC) locus in patients with multiple sclerosis (MS). OBJECTIVES The objective of this paper is to analyse the association of the locus with MS susceptibility and its relationship with intrathecal immunoglobulin (Ig) parameters. METHODS We genotyped the rs11621145 variant, located at the IGHC locus, in 2726 patients with MS and 2133 healthy controls… CONTINUE READING
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International Multiple Sclerosis

Consortium, AH Beecham, NA Patsopoulos
  • Nat Genet
  • 2013

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