A new resistance gene, linB, conferring resistance to lincosamides by nucleotidylation in Enterococcus faecium HM1025.

@article{Bozdoan1999ANR,
  title={A new resistance gene, linB, conferring resistance to lincosamides by nucleotidylation in Enterococcus faecium HM1025.},
  author={B{\"u}lent Bozdoğan and L Berrezouga and Michelle S Kuo and David A. Yurek and Kathleen A Farley and Brian J Stockman and Roland Leclercq},
  journal={Antimicrobial agents and chemotherapy},
  year={1999},
  volume={43 4},
  pages={925-9}
}
Resistance to lincomycin and clindamycin in the clinical isolate Enterococcus faecium HM1025 is due to a ribosomal methylase encoded by an ermAM-like gene and the plasmid-mediated inactivation of these antibiotics. We have cloned and determined the nucleotide sequence of the gene responsible for the inactivation of lincosamides, linB. This gene encodes a 267-amino-acid lincosamide nucleotidyltransferase. The enzyme catalyzes 3(5'-adenylation) (the adenylation of the hydroxyl group in position 3… CONTINUE READING

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