A new regulatory protein, KSRP, mediates exon inclusion through an intronic splicing enhancer.

@article{Min1997ANR,
  title={A new regulatory protein, KSRP, mediates exon inclusion through an intronic splicing enhancer.},
  author={Hang Jun Min and Chris W Turck and Jacek Rostowski Milan Nikolic and Douglas L. Black},
  journal={Genes & development},
  year={1997},
  volume={11 8},
  pages={1023-36}
}
We have purified and cloned a new splicing factor, KSRP. KSRP is a component of a multiprotein complex that binds specifically to an intronic splicing enhancer element downstream of the neuron-specific c-src N1 exon. This 75-kD protein induces the assembly of five other proteins, including the heterogeneous nuclear ribonucleoprotein F, onto the splicing enhancer. The sequence of the KSRP cDNA indicates that the protein contains four K homology RNA-binding domains and an unusual carboxy-terminal… CONTINUE READING
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