A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4

@article{Serrano1993ANR,
  title={A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4},
  author={M Serrano and Gregory J. Hannon and David H. Beach},
  journal={Nature},
  year={1993},
  volume={366},
  pages={704-707}
}
THE division cycle of eukaryotic cells is regulated by a family of protein kinases known as the cyclin-dependent kinases (CDKs)1,2. The sequential activation of individual members of this family and their consequent phosphorylation of critical substrates promotes orderly progression through the cell cycle3,4. The complexes formed by CDK4 and the D-type cyclins have been strongly implicated in the control of cell proliferation during the G1 phase3–6. CDK4 exists, in part, as a multi-protein… 

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