A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4

@article{Serrano1993ANR,
  title={A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4},
  author={M. Serrano and G. Hannon and D. Beach},
  journal={Nature},
  year={1993},
  volume={366},
  pages={704-707}
}
THE division cycle of eukaryotic cells is regulated by a family of protein kinases known as the cyclin-dependent kinases (CDKs)1,2. The sequential activation of individual members of this family and their consequent phosphorylation of critical substrates promotes orderly progression through the cell cycle3,4. The complexes formed by CDK4 and the D-type cyclins have been strongly implicated in the control of cell proliferation during the G1 phase3–6. CDK4 exists, in part, as a multi-protein… Expand
Formation of p27-CDK complexes during the human mitotic cell cycle.
  • T. Soos, H. Kiyokawa, +7 authors A. Koff
  • Biology, Medicine
  • Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research
  • 1996
Conditional binding to and cell cycle-regulated inhibition of cyclin-dependent kinase complexes by p27Kip1.
Regulation of CDK7–Carboxyl-Terminal Domain Kinase Activity by the Tumor Suppressor p16INK4A Contributes to Cell Cycle Regulation
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