A new recombinant MnSOD prevents the cyclosporine A-induced renal impairment.


BACKGROUND Cyclosporine A (CsA) is one of the most frequently used anticalcineurinic drugs for preventing graft rejection and autoimmune disease. Its use is hampered by nephrotoxic effects, namely an impairment of the glomerular filtration rate (GFR) and hypertension. Evidence suggests that reactive oxygen species (ROS) play a causal role in the… (More)
DOI: 10.1093/ndt/gft020


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