A new reagent for stable thiol-specific conjugation.

  title={A new reagent for stable thiol-specific conjugation.},
  author={George O. Badescu and Penny Bryant and Julia Swierkosz and Farzad Khayrzad and Estera Pawlisz and Monika Farys and Yuehua Cong and Maurizio Muroni and Norbert Rumpf and Steve Brocchini and Antony Godwin},
  journal={Bioconjugate chemistry},
  volume={25 3},
Many clinically used protein therapeutics are modified to increase their efficacy. Example modifications include the conjugation of cytotoxic drugs to monoclonal antibodies or poly(ethylene glycol) (PEG) to proteins and peptides. Monothiol-specific conjugation can be efficient and is often accomplished using maleimide-based reagents. However, maleimide derived conjugates are known to be susceptible to exchange reactions with endogenous proteins. To address this limitation in stability, we have… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 10 extracted citations

Similar Papers

Loading similar papers…