A new rat model exhibiting both ovarian and metabolic characteristics of polycystic ovary syndrome.

@article{Manners2007ANR,
  title={A new rat model exhibiting both ovarian and metabolic characteristics of polycystic ovary syndrome.},
  author={Louise Manner{\aa}s and Stefan Cajander and Agneta Holm{\"a}ng and Zamira Seleskovic and Theodore Lystig and Malin L{\"o}nn and Elisabet Stener-Victorin},
  journal={Endocrinology},
  year={2007},
  volume={148 8},
  pages={3781-91}
}
Polycystic ovary syndrome (PCOS) is a complex endocrine and metabolic disorder associated with ovulatory dysfunction, hyperandrogenism, abdominal obesity, and insulin resistance. However, its etiology is unclear, and its management is often unsatisfactory or requires a diversified approach. Here, we describe a new rat PCOS model, the first to exhibit both ovarian and metabolic characteristics of the syndrome. Female rats received the nonaromatizable androgen dihydrotestosterone (DHT) or the… CONTINUE READING
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