A new rabbit monoclonal antibody (4B5) for the immunohistochemical (IHC) determination of the HER2 status in breast cancer: comparison with CB11, fluorescence in situ hybridization (FISH), and interlaboratory reproducibility.

@article{Powell2007ANR,
  title={A new rabbit monoclonal antibody (4B5) for the immunohistochemical (IHC) determination of the HER2 status in breast cancer: comparison with CB11, fluorescence in situ hybridization (FISH), and interlaboratory reproducibility.},
  author={William C Powell and David G. Hicks and Nichole L Prescott and Shannon M Tarr and Simas Laniauskas and Tristin Williams and Sarah P. Short and James D. Pettay and Raymond B. Nagle and David J Dabbs and Katherine M. Scott and Richard W Brown and Thomas M. Grogan and Patrick C. Roche and Raymond R. Tubbs},
  journal={Applied immunohistochemistry & molecular morphology : AIMM},
  year={2007},
  volume={15 1},
  pages={94-102}
}
The 2 methodologies in current clinical use to assess HER2 status in breast cancer are: fluorescence in situ hybridization (FISH) (gene amplification) and immunohistochemistry (protein over-expression). A consistent finding has been that 3% to 15% of breast cancers over-express HER2 protein without evidence for gene amplification. Accurate determination of the HER2 status has implications for selecting patients most likely to respond to trastuzumab. We report here our preliminary experience… CONTINUE READING

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