Corpus ID: 32869345

A new pyrrolizidine alkaloid metabolite, 19-hydroxysenecionine isolated from mouse hepatic microsomes in vitro.

@article{Eastman1982ANP,
  title={A new pyrrolizidine alkaloid metabolite, 19-hydroxysenecionine isolated from mouse hepatic microsomes in vitro.},
  author={D. Eastman and H. J. Segall},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={1982},
  volume={10 6},
  pages={
          696-9
        }
}
  • D. Eastman, H. J. Segall
  • Published 1982
  • Chemistry, Medicine
  • Drug metabolism and disposition: the biological fate of chemicals
  • The in vitro mouse hepatic microsomal metabolism of the macrocyclic pyrrolizidine alkaloid senecionine was studied by high-performance liquid chromatography. A muBondapak-C18 reverse-phase system was developed to study the senecionine metabolites over a wide range of polarities. Methods were further developed for the isolation of each individual metabolite. Senecic acid, senecionine N-oxide, and 19-hydroxysenecionine, a new metabolite, were isolated from the microsomal enzyme system of BALB/c… CONTINUE READING
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