A new proposal for benefit-less-risk analysis in clinical trials.

@article{ChuangStein1994ANP,
  title={A new proposal for benefit-less-risk analysis in clinical trials.},
  author={Christy Chuang-Stein},
  journal={Controlled clinical trials},
  year={1994},
  volume={15 1},
  pages={30-43}
}
In this paper, we propose a method to discount the observed benefit of a treatment by the observed risk in order to facilitate the benefit-less-risk comparison of treatments in a clinical trial. The discounting, applied to each individual in a trial, utilizes a method proposed by Chuang-Stein and co-authors to consolidate the safety data collected in the trial. The collating of the safety information allows one to estimate quantitatively the risk experienced by each individual, and therefore… CONTINUE READING