A new promoter polymorphism in the gene of lipopolysaccharide receptor CD14 is associated with expired myocardial infarction in patients with low atherosclerotic risk profile.

@article{Unkelbach1999ANP,
  title={A new promoter polymorphism in the gene of lipopolysaccharide receptor CD14 is associated with expired myocardial infarction in patients with low atherosclerotic risk profile.},
  author={K Unkelbach and Andreas Gardemann and Michael Kostrzewa and Monika Philipp and Harald Tillmanns and Werner Haberbosch},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={1999},
  volume={19 4},
  pages={932-8}
}
Recent findings suggest that inflammation plays a role in atherosclerosis and its acute complications. Cellular response in infections with Gram-negative bacteria is mediated by bacterial lipopolysaccharide (LPS), which activates monocytes to expression of cytokines, growth factors, and procoagulatory factors via LPS receptor CD14. Endothelial cells and smooth muscle cells are stimulated by a complex of LPS and soluble CD14. In this study, LPS receptor CD14 was analyzed to find genetic variants… CONTINUE READING
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