A new procedure for group sequential analysis in clinical trials.

@article{Falissard1992ANP,
  title={A new procedure for group sequential analysis in clinical trials.},
  author={Bruno Falissard and Joseph Lellouch},
  journal={Biometrics},
  year={1992},
  volume={48 2},
  pages={373-88}
}
Since Pocock (1977, Biometrika 64, 191-199), many methods have been developed for group sequential analysis of clinical trials. However, these methods remain underemployed partly because of inconsistencies of sequential testing [Berry (1987, The Statistician 36, 181-189)]. This paper considers a new approach, which, by requiring that a succession of interim analyses be significant at the alpha level, both preserves the overall significance level alpha and does not present some of the… CONTINUE READING

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