A new principal component analysis-based approach for testing "similarity" of drug dissolution profiles.

@article{Maggio2008ANP,
  title={A new principal component analysis-based approach for testing "similarity" of drug dissolution profiles.},
  author={Rub{\'e}n M. Maggio and Patricia M. Castellano and Teodoro S Kaufman},
  journal={European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences},
  year={2008},
  volume={34 1},
  pages={66-77}
}
A new approach for testing batch "similarity" through comparison of drug dissolution profiles, based on principal component analysis with the establishment of a confidence region (PCA-CR), is presented. The dissolution curves corresponding to three brands each of Furosemide and Acetaminophen tablets, taken as model drugs, were prepared by dissolution… CONTINUE READING