A new preparation method for protein loaded poly(D, L-lactic-co-glycolic acid) microspheres and protein release mechanism study.

@article{Park1998ANP,
  title={A new preparation method for protein loaded poly(D, L-lactic-co-glycolic acid) microspheres and protein release mechanism study.},
  author={Tae Gwan Park and H Yong Lee and Y Sung Nam},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  year={1998},
  volume={55 2-3},
  pages={181-91}
}
A new method for encapsulating a model protein, lysozyme into hydrophilic uncapped poly(d,l-lactic-co-glycolic acid) (PLGA) microspheres was developed using an oil/water (O/W) single emulsion technique. Lysozyme powder, which was prepared from lyophilization after adjusting a lysozyme solution pH at 3, was molecularly dissolved in a co-solvent system composed of dimethylsulfoxide (DMSO) and methylene chloride. The resulting organic solution containing PLGA was directly emulsified into an… CONTINUE READING
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