A new porcine in vivo animal model of disc degeneration: response of anulus fibrosus cells, chondrocyte-like nucleus pulposus cells, and notochordal nucleus pulposus cells to partial nucleotomy.

@article{Omlor2009ANP,
  title={A new porcine in vivo animal model of disc degeneration: response of anulus fibrosus cells, chondrocyte-like nucleus pulposus cells, and notochordal nucleus pulposus cells to partial nucleotomy.},
  author={Georg W Omlor and Andreas G. Nerlich and Hans-Joachim Wilke and Michael Pfeiffer and Helga Lorenz and Markus Schaaf-Keim and Helge Bertram and Wiltrud Richter and Claus Carstens and Thorsten Guehring},
  journal={Spine},
  year={2009},
  volume={34 25},
  pages={
          2730-9
        }
}
STUDY DESIGN In vivo animal study. OBJECTIVES To describe a new porcine disc degeneration model, and to analyze disc remodeling and degeneration after nucleotomy with special view to the different nucleus pulposus (NP) cell types. SUMMARY OF BACKGROUND DATA Thus far, predominantly smaller animals were used for disc degeneration models; however, such small discs were inappropriate to investigate cell implementation therapies. Though notochordal cells (NCs) are important for disc formation… CONTINUE READING
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