A new player in cartilage homeostasis: adiponectin induces nitric oxide synthase type II and pro-inflammatory cytokines in chondrocytes.

@article{Lago2008ANP,
  title={A new player in cartilage homeostasis: adiponectin induces nitric oxide synthase type II and pro-inflammatory cytokines in chondrocytes.},
  author={R A Sotelo Lago and Rodolfo G{\'o}mez and M Jes{\'u}s {\'A}lvarez Otero and Francisca Lago and Rosal{\'i}a Gallego and Carlos Di{\'e}guez and Juan J G{\'o}mez-Reino and Oreste Gualillo},
  journal={Osteoarthritis and cartilage},
  year={2008},
  volume={16 9},
  pages={1101-9}
}
OBJECTIVE Recent studies revealed a close connection between adipose tissue, adipokines and articular degenerative inflammatory diseases such as rheumatoid arthritis (RA) and osteoarthritis (OA). The goal of this work was to investigate the activity of adiponectin in human and murine chondrocytes and to study its functional role in the modulation of nitric oxide synthase type II (NOS2). For completeness, interleukin (IL)-6, IL-1beta, matrix metalloproteinase (MMP)-2, MMP-3, MMP-9, tissue… CONTINUE READING
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Changes in fat-derived hormones plasma concentrations: adiponectin, leptin, resistin, and visfatin in rheumatoid arthritis subjects

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