A new phospholipase-C–calcium signalling pathway mediated by cyclic AMP and a Rap GTPase

@article{Schmidt2001ANP,
  title={A new phospholipase-C–calcium signalling pathway mediated by cyclic AMP and a Rap GTPase},
  author={Martina Schmidt and Sandrine Evellin and Paschal A. Oude Weernink and Frank vom Dorp and Holger Rehmann and Jon W. Lomasney and Karl Heinz Jakobs},
  journal={Nature Cell Biology},
  year={2001},
  volume={3},
  pages={1020-1024}
}
Stimulation of phosphoinositide-hydrolysing phospholipase C (PLC) generating inositol-1,4,5-trisphosphate is a major calcium signalling pathway used by a wide variety of membrane receptors, activating distinct PLC-β or PLC-γ isoforms. Here we report a new PLC and calcium signalling pathway that is triggered by cyclic AMP (cAMP) and mediated by a small GTPase of the Rap family. Activation of the adenylyl cyclase-coupled β2-adrenoceptor expressed in HEK-293 cells or the endogenous receptor for… CONTINUE READING
Highly Influential
This paper has highly influenced 14 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 130 extracted citations

Similar Papers

Loading similar papers…