A new pharmacological effect of salicylates: inhibition of NFAT-dependent transcription.

@article{Aceves2004ANP,
  title={A new pharmacological effect of salicylates: inhibition of NFAT-dependent transcription.},
  author={M{\'o}nica Aceves and Ana Isabel Due{\~n}as and Cristina Luna G{\'o}mez and Edurne San Vicente and Mariano Crespo and C{\'a}rmen Garcia-Rodriguez},
  journal={Journal of immunology},
  year={2004},
  volume={173 9},
  pages={5721-9}
}
The anti-inflammatory effects of salicylates, originally attributed to inhibition of cyclooxygenase activity, are currently known to involve additional mechanisms. In this study we investigated the possible modulation by salicylates of NFAT-mediated transcription in lymphocytic and monocytic cell lines. RNase protection assays showed that 2-acetoxy-4-trifluoromethylbenzoic acid (triflusal) inhibited, in a dose-dependent manner, mRNA expression of several cytokine genes, most of which are NFAT… CONTINUE READING