A new perspective on radiation resistance based on Deinococcus radiodurans

  title={A new perspective on radiation resistance based on Deinococcus radiodurans},
  author={Michael J. Daly},
  journal={Nature Reviews Microbiology},
  • M. Daly
  • Published 1 March 2009
  • Biology
  • Nature Reviews Microbiology
In classical models of radiation toxicity, DNA is the molecule that is most affected by ionizing radiation (IR). However, recent data show that the amount of protein damage caused during irradiation of bacteria is better related to survival than to DNA damage. In this Opinion article, a new model is presented in which proteins are the most important target in the hierarchy of macromolecules affected by IR. A first line of defence against IR in extremely radiation-resistant bacteria might be the… 
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eath by protein damage in irradiated cells
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Death by protein damage in irradiated cells.
The diversity and commonalities of the radiation-resistance mechanisms of Deinococcus and its up-to-date applications
This article summarizes the latest research on the radiation-resistance mechanisms of Deinococcus and prospects its biotechnological application potentials.
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It is stressed that the initial physical and chemical changes induced by radintion are extremely rapid, whereas subsequent mutations and death require processes of cell metabolism that take a comparatively long time before they become manifest.
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This work discusses different hypotheses and possibilities that have been suggested to contribute to radioresistance and proposes that D. radiodurans combines a variety of physiological tools that are tightly coordinated.
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DNA repair in the extremely radioresistant bacterium Deinococcus radiodurans
Deinococcus radiodurans may serve as an easily accessible model system for the double‐strand‐break‐initiated interchromosomal recombination that occurs in eukaryotic cells during mitosis and meiosis.