A new perspective on old drugs: non-mitotic actions of tubulin-binding drugs play a major role in cancer treatment.

@article{Frst2013ANP,
  title={A new perspective on old drugs: non-mitotic actions of tubulin-binding drugs play a major role in cancer treatment.},
  author={Robert F{\"u}rst and Angelika M. Vollmar},
  journal={Die Pharmazie},
  year={2013},
  volume={68 7},
  pages={478-83}
}
Microtubule-targeting agents (MTAs) are the most frequently used anti-cancer drugs. They can be divided into tubulin stabilizing and destabilizing agents. Their mode of action has been ascribed to their ability to interfere with the spindle apparatus and, thus, to block mitosis leading to tumor cell death. However, this view has been challenged in the last years and it became increasingly evident that non-mitotic actions of MTAs, i.e. their ability to affect the dynamics of interphase… CONTINUE READING