A new perspective on Darwin’s Pangenesis

  title={A new perspective on Darwin’s Pangenesis},
  author={Yongsheng Liu},
  journal={Biological Reviews},
In 1868 Charles Darwin proposed Pangenesis, a developmental theory of heredity. He suggested that all cells in an organism are capable of shedding minute particles he called gemmules, which are able to circulate throughout the body and finally congregate in the gonads. These particles are then transmitted to the next generation and are responsible for the transmission of characteristics from parent to offspring. If any cells of the parent undergo changes as a result of environmental change… 
Revisiting Darwin ’ s theory of heredity —
The discovery of circulating nucleic acids indicates that there are indeed inherited molecules which can move between cells of the organism, providing evidence for the chemical existence of Darwin’s gemmules.
Charles Darwin's Theory of Pangenesis
Around the turn of the twentieth century, biologists replaced the theory of pangenesis with germ plasm theory and then with chromosomal theories of inheritance, and they replaced the concept of gemmules with that of genes.
Does Darwin's Pangenesis have fatal flaws?
In a recent issue of International Journal of Epidemiology, Kuzawa stated that Darwin lacked an understanding of the material basis of heredity, and his Pangenesis had fatal flaws. It is likely that
The History and Reception of Charles Darwin’s Hypothesis of Pangenesis
It is argued that critics largely interpreted Variation as an extension of On the Origin of Species by Means of Natural Selection (1859), while pangenesis was an Extension of natural selection.
Darwin's Pangenesis and Medical Genetics.
Gemmules and Elements: On Darwin’s and Mendel’s Concepts and Methods in Heredity
Mendel took the study of the transmission of traits and its causes out of natural history and transformed it into a scientific field of research, and contributed crucially to the explanation of the existence of stable variations as the basis for natural selection.
Circulating nucleic acids and Darwin's gemmules
Pangenesis is a highly comprehensive theory Darwin constructed to explain a far wider range of phenomena than Mendel had considered, which not only explains graft hybridization and the inheritance of acquired characters, but also explains dominance inheritance, reversion, regeneration, xenia, telegony and many other facts.
Darwin’s Pangenesis and Epigenetic Effects on Brain Functions


The Development of Francis Galton's Ideas on the Mechanism of Heredity
  • M. Bulmer
  • Psychology
    Journal of the history of biology
  • 1999
Galton greeted Darwin's theory of pangenesis with enthusiasm, and tried to test the assumption that the hereditary particles circulate in the blood by transfusion experiments on rabbits. The failure
MR. DARWIN, in his letter to NATURE of April the 27th, says : “The fundamental laws of growth, reproduction, inheritance, &c, are so closely similar throughout the whole organic kingdom that the
Further evidence for Darwin's pangenesis.
It is proposed that once the term gemmule has been replaced by mRNA, Darwin's pangenesis will revive, indicating an important step in biology.
The Origin of Species Revisited: A Victorian who Anticipated Modern Developments in Darwin's Theory
In 1858 papers were presented on evolution at the Linnean Society in London by Charles Darwin and Alfred Russel Wallace. The following year Darwin's magnum opus was published—On the Origin of Species
Prehistory of the Notion of Circulating Nucleic Acids in Plasma/Serum (CNAPS)
It is suggested that DNA was circulating between the mentor and pupil plants and assumed that some nucleic acid molecules bearing genetic information could enter the somatic and reproductive cells of the pupil plant at a propitious moment and remain active.
Further Attempts to Induce Heritable Changes in the Fowl by Inter-Species Blood Transfer
It is found that birds of a White Leghorn strain repeatedly injected with blood from the gray guinea-fowl produced progeny with some gray or black-flecked feathers in the second and later generations, and Buschinelli was unable to effect hereditary modifications in the domestic fowl as a result of repeated inter-breed, inter-species and inter-family blood injections.
Historical and modern genetics of plant graft hybridization.
Reversion: going back to Darwin's works.
A failure to induce heritable changes in four generations of the White Leghorn chicken by inter- and intra-specific blood transfusion * †
A three-year study to test the efficacy of inter- and intra-specific blood transfusions in domestic poultry for inducing heritable changes in the recipients found no evidence of heritable shifts in the direction of the donor organism was discerned among birds belonging to either of the two treated lines.
Elemente der exakten Erblichkeitslehre
WITHIN the last few years the output of exact experimental work upon phenomena of heredity has been very large, and the progress made, as compared with that of the previous forty years, has been