A new peptide with membrane-permeable function derived from human circadian proteins.

@article{Peng2004ANP,
  title={A new peptide with membrane-permeable function derived from human circadian proteins.},
  author={Tao Peng and Ying-hui Liu and Chun-Lei Yang and Chaomin Wan and Yao-qi Wang and Zheng-rong Wang},
  journal={Acta biochimica et biophysica Sinica},
  year={2004},
  volume={36 9},
  pages={629-36}
}
Basic peptides such as human immunodeficiency virus type 1 (HIV-1) Tat-(48-60) and Drosophila Antennapedia-(43-58) have been reported to have a membrane permeability and a carrier function for intracellular protein delivery. Based on the fluorescence microscopic observations of the vascular endothelial cells (ECV-304) and the primary cultured neuroglial cells, we found that human Clock protein DNA-binding peptide [residue 35-47, hClock-(35-47)] had a translocation activity very similar to Tat… CONTINUE READING

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