A new pathway for protein export in Saccharomyces cerevisiae.


Several physiologically important proteins lack a classical secretory signal sequence, yet they are secreted from cells. To investigate the secretion mechanism of such proteins, a representative mammalian protein that is exported by a nonclassical mechanism, galectin-1, has been expressed in yeast. Galectin-1 is exported across the yeast plasma membrane, and this export does not require the classical secretory pathway nor the yeast multidrug resistance-like protein Ste6p, the transporter for the peptide a factor. A screen for components of the export machinery has identified genes that are involved in nonclassical export. These findings demonstrate a new pathway for protein export that is distinct from the classical secretory pathway in yeast.

Extracted Key Phrases

6 Figures and Tables

Citations per Year

854 Citations

Semantic Scholar estimates that this publication has 854 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Cleves1996ANP, title={A new pathway for protein export in Saccharomyces cerevisiae.}, author={Ann E. Cleves and David N. Cooper and S H Barondes and Regis B. Kelly}, journal={The Journal of cell biology}, year={1996}, volume={133 5}, pages={1017-26} }