A new pathway for heavy metal detoxification in animals. Phytochelatin synthase is required for cadmium tolerance in Caenorhabditis elegans.

@article{Vatamaniuk2001ANP,
  title={A new pathway for heavy metal detoxification in animals. Phytochelatin synthase is required for cadmium tolerance in Caenorhabditis elegans.},
  author={Olena K. Vatamaniuk and Elizabeth A. Bucher and James T Ward and Philip A. Rea},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 24},
  pages={20817-20}
}
Increasing emissions of heavy metals such as cadmium, mercury, and arsenic into the environment pose an acute problem for all organisms. Considerations of the biochemical basis of heavy metal detoxification in animals have focused exclusively on two classes of peptides, the thiol tripeptide, glutathione (GSH, gamma-Glu-Cys-Gly), and a diverse family of cysteine-rich low molecular weight proteins, the metallothioneins. Plants and some fungi, however, not only deploy GSH and metallothioneins for… CONTINUE READING
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