A new oxytocin-saporin cytotoxin for lesioning oxytocin-receptive neurons in the rat hindbrain.

@article{Baskin2010ANO,
  title={A new oxytocin-saporin cytotoxin for lesioning oxytocin-receptive neurons in the rat hindbrain.},
  author={Denis G. Baskin and Francis Y Kim and Richard Wayne Gelling and B Jordan Russell and Michael J. Schwartz and Gregory J. Morton and Hyagriv N Simhan and Daniel H. Moralejo and James E. Blevins},
  journal={Endocrinology},
  year={2010},
  volume={151 9},
  pages={4207-13}
}
Evidence suggests that release of oxytocin in the nucleus tractus solitarius (NTS) of the hindbrain from descending projections that originate in the paraventricular nucleus can inhibit food intake by amplifying the satiety response to cholecystokinin (CCK). To further evaluate this mechanism in rats, we used a novel cytotoxin, saporin conjugated to oxytocin (OXY-SAP), a compound designed to destroy cells that express oxytocin receptors (OXYr). OXY-SAP was injected directly into the NTS to… CONTINUE READING
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