A new organocatalytic concept for asymmetric α-alkylation of aldehydes.

Abstract

The organocatalytic asymmetric α-alkylation of aldehydes by 1,6-conjugated addition of enamines to p-quinone methides is described. Employing a newly developed class of chiral secondary amine catalysts, α-diarylmethine-substituted aldehydes with two contiguous stereocenters have been synthesized in a simple manner with good diastereocontrol and excellent enantioselectivity.

DOI: 10.1021/ja510475n

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Cite this paper

@article{Caruana2014ANO, title={A new organocatalytic concept for asymmetric α-alkylation of aldehydes.}, author={Lorenzo Caruana and Florian Kniep and Tore Kiilerich Johansen and Pernille H Poulsen and Karl Anker J\orgensen}, journal={Journal of the American Chemical Society}, year={2014}, volume={136 45}, pages={15929-32} }