A new oral erosion controlled drug delivery system with a late burst in the release profile.

A new oral erosion controlled drug delivery system on the basis of polyvinyl alcohols with a late burst in the release profile is developed. This late burst occurs after addition of sparingly soluble substances, either excipients like carboxylic acids and neutral cellulose or drugs like theophylline and theobromine. The onset time between 4 and 12 h and the… CONTINUE READING