A new nomenclature for int-1 and related genes: The Wnt gene family

  title={A new nomenclature for int-1 and related genes: The Wnt gene family},
  author={Roel Nusse and A. M. Brown and Jackie Papkoff and Peter J. Scambler and Gregory M Shackleford and A Mcmahon and Randall Moon and Harold Varmus},
Wnt7a Promotes the Occurrence and Development of Colorectal Adenocarcinoma
Wnt7a promotes the occurrence and development of colorectal adenocarcinoma, and the down-regulation of Wnt7A reduced the proliferation ability of colOREctal cancer cells.
Wnt Signaling and Drug Resistance in Cancer
Recent studies extend understanding of this ancient signaling pathway and describe the development and improvement of anti-Wnt therapeutic modalities for cancer.
A Tale of Two Signals: AR and WNT in Development and Tumorigenesis of Prostate and Mammary Gland
The role of AR signaling and its interaction with WNT signaling in these two hormone-related cancer types are highly context-dependent and the possible therapeutic application of drugs that target both AR and WNT/β-catenin pathways is reviewed.
Biotechnological approaches to cardiac differentiation of human induced pluripotent stem cells
A fast and efficient stage-specific differentiation protocol suitable for the iPSC lines used in this work, derived from human keratinocytes is identified, which can reproducibly obtain close to 50% cardiomyocytes after 15 days of differentiation.
Regulation of lubricin/superficial zone protein by Wnt signalling in bovine synoviocytes
Novel insights are provided into the role of the Wnt signalling pathways in SZP accumulation in synoviocytes and their roles in the homeostasis of normal joints.
Wnts in development : Focus on midbrain
This thesis work investigated signaling through Wnt5a and LRP6 (a Wnt receptor thought to bind Wnt1/Wnt3a, but not Wnt4a), as well as the roles of Wnt 1, Wnt 5a, LRP 6, s FRP1 and sFRP2 (secreted proteins which reportedly binds Wnts to antagonize their function) in the development of the midbrain and DA neurons.
Overview of Three Proliferation Pathways (Wnt, Notch, and Hippo) in Intestine and Immune System and Their Role in Inflammatory Bowel Diseases (IBDs)
The components and signaling of Wnt, Notch, and Hippo pathways and their role in the intestine and immune system are summarized and latest scientific literature on the crosstalk among these three signaling pathways in IBD is reviewed.
High quality genomes corroborate 29 chromosomes of the haploid Hyles (Lepidoptera: Sphingidae) karyotype
High Peaks of divergence surrounding wingless/wnt-1 and cortex provide candidate genomic areas in which wing patterns are determined in this genus.


Mammary tumorigenesis in feral mice: identification of a new int locus in mouse mammary tumor virus (Czech II)-induced mammary tumors
A population of Mus musculus subsp. musculus (Czech II), recently isolated from the wild, lack endogenous mouse mammary tumor virus (MMTV) proviral genomes. Some of these mice carry an infectious
Expression of multiple novel Wnt-1/int-1-related genes during fetal and adult mouse development.
The view that the Wnt-1/int-1 family constitutes a large family of signaling peptides with diverse roles in mouse development is supported.
Isolation of a human gene with protein sequence similarity to human and murine int‐1 and the Drosophila segment polarity mutant wingless.
An expressed gene sequence which was identified by the isolation of a methylation free CpG island from human chromosome 7 has been cloned from a human lung cDNA library and shows marked similarity with human and murine int‐1 and their Drosophila homolog wingless (Dint‐1).
Nucleotide sequence, chromosomal localization and developmental expression of the mouse int-1-related gene.
A role for m-irp in the development of fetal allantoic communication is suggested after analysis of polymerase chain reaction, amplified cDNA, and genomic sequences strongly suggests that a single-base substitution has created a new 5' splice site 17 bp 5' of a highly conservedsplice site.