A new natriuretic peptide in porcine brain

@article{Sudoh1988ANN,
  title={A new natriuretic peptide in porcine brain},
  author={Tetsuji Sudoh and Kenji Kangawa and Naoto Minamino and Hisayuki Matsuo},
  journal={Nature},
  year={1988},
  volume={332},
  pages={78-81}
}
Atrial natriuretic peptide (ANP), a hormone secreted from mammalian atria, regulates the homoeostatic balance of body fluid and blood pressure1–3. ANP-like immunoreactivity is also present in the brain, suggesting that the peptide functions as a neuro-peptide4,5. We report here identification in porcine brain of a novel peptide of 26 amino-acid residues, eliciting a pharmacological spectrum very similar to that of ANP, such as natriuretic-diuretic, hypotensive and chick rectum relaxant… CONTINUE READING
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