A new natriuretic peptide in porcine brain

@article{Sudoh1988ANN,
  title={A new natriuretic peptide in porcine brain},
  author={Tetsuji Sudoh and Kenji Kangawa and Naoto Minamino and Hisayuki Matsuo},
  journal={Nature},
  year={1988},
  volume={332},
  pages={78-81}
}
Atrial natriuretic peptide (ANP), a hormone secreted from mammalian atria, regulates the homoeostatic balance of body fluid and blood pressure1–3. ANP-like immunoreactivity is also present in the brain, suggesting that the peptide functions as a neuro-peptide4,5. We report here identification in porcine brain of a novel peptide of 26 amino-acid residues, eliciting a pharmacological spectrum very similar to that of ANP, such as natriuretic-diuretic, hypotensive and chick rectum relaxant… 
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1,812 Citations

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6 Thyroid Disorders and Brain Natriuretic Peptide
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The structure of atrial natriuretic peptide (ANP) was first discovered in 1984 and a molecule, which resembled ANP, was isolated from a pig brain in following years, and it was found that it had similar physiological effects to diuretic and vasorelaxant actions.
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Enzyme assays and NPRA-specific Western blots performed on tissues from wild-type mice demonstrate that ANP-activated cGMP synthesis provides a good index of NPRA protein expression, suggesting the presence of a novel receptor in these tissues that prefers BNP over ANP.
The presence of brain natriuretic peptide of 12,000 daltons in porcine heart.
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    The American journal of medicine
  • 2003
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References

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Identification of alpha atrial natriuretic peptide [4-28] and [5-28] in porcine brain.
Molecular forms of atrial natriuretic polypeptides in mammalian tissues and plasma.
Cloning and sequence analysis of cDNA encoding a precursor for human atrial natriuretic poly peptide
TLDR
The cloning and sequence analysis of the cDNA of human atrial mRNA encoding a precursor of α-hANP is reported, which encodes γ-human atrial natriuretic polypeptide (γ-hAnP) of 13,000 MW, whose C-terminal 28 amino acid residues may be processed as α- hANP.
Structural identification of β- and γ-human atrial natriuretic polypeptides
TLDR
The purification and sequence analysis of two novel hANPs of higher Mr, β- and γ-hANP, both of which exhibit natriuretic and hypotensive activity are reported, revealing that the largest form of hANP is processed directly from a 151-residue precursor9 by removal of a 26-Residue signal peptide.
Purification and complete amino acid sequence of α-human atrial natriuretic polypeptide (α-hANP)
Atrial natriuretic factor: a hormone produced by the heart
TLDR
This hormone, described in 1981 as atrial natriuretic factor (ANF), is diuretic, hypotensive, and has an inhibitory effect on renin and aldosterone secretion.
Bioactive cardiac substances: potent vasorelaxant activity in mammalian atria.
TLDR
It appears that atria possess at least two peptides that elicit smooth muscle relaxation and natriuresis, suggesting an endogenous system of fluid volume regulation.
Structure of dog and rabbit precursors of atrial natriuretic polypeptides deduced from nucleotide sequence of cloned cDNA.
Molecular forms of atrial natriuretic polypeptides circulating in human plasma.
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