A new natriuretic peptide in porcine brain

@article{Sudoh1988ANN,
  title={A new natriuretic peptide in porcine brain},
  author={Tetsuji Sudoh and Kenji Kangawa and Naoto Minamino and Hisayuki Matsuo},
  journal={Nature},
  year={1988},
  volume={332},
  pages={78-81}
}
Atrial natriuretic peptide (ANP), a hormone secreted from mammalian atria, regulates the homoeostatic balance of body fluid and blood pressure1–3. ANP-like immunoreactivity is also present in the brain, suggesting that the peptide functions as a neuro-peptide4,5. We report here identification in porcine brain of a novel peptide of 26 amino-acid residues, eliciting a pharmacological spectrum very similar to that of ANP, such as natriuretic-diuretic, hypotensive and chick rectum relaxant… 
Biochemistry of a Natriuretic Peptide Family
TLDR
There is much more to be learned for understanding the still puzzling significance of ANP, which is known to be secreted from the heart, circulates in the blood and participates in the regulation of salts-water balance and blood pressure.
Thyroid Disorders and Brain Natriuretic Peptide
TLDR
The structure of atrial natriuretic peptide (ANP) was first discovered in 1984 and a molecule, which resembled ANP, was isolated from a pig brain in following years, and it was found that it had similar physiological effects to diuretic and vasorelaxant actions.
6 Thyroid Disorders and Brain Natriuretic Peptide
TLDR
The structure of atrial natriuretic peptide (ANP) was first discovered in 1984 and a molecule, which resembled ANP, was isolated from a pig brain in following years, and it was found that it had similar physiological effects to diuretic and vasorelaxant actions.
Evidence for a novel natriuretic peptide receptor that prefers brain natriuretic peptide over atrial natriuretic peptide.
TLDR
Enzyme assays and NPRA-specific Western blots performed on tissues from wild-type mice demonstrate that ANP-activated cGMP synthesis provides a good index of NPRA protein expression, suggesting the presence of a novel receptor in these tissues that prefers BNP over ANP.
Effects of atrial natriuretic peptide, brain natriuretic peptide and urodilatin on histamine induced bronchoconstriction in the conscious guinea pig
TLDR
The purpose of this study was to elucidate the potential protective action of these peptides against histamine-induced bronchoconstriction in the conscious guinea pig.
Identification of new atrial natriuretic peptides in frog heart.
Brain natriuretic peptide: a marker for subclinical cardiovascular disease?
  • D. Gardner
  • Medicine, Biology
    The American journal of medicine
  • 2003
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References

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TLDR
The cloning and sequence analysis of the cDNA of human atrial mRNA encoding a precursor of α-hANP is reported, which encodes γ-human atrial natriuretic polypeptide (γ-hAnP) of 13,000 MW, whose C-terminal 28 amino acid residues may be processed as α- hANP.
Structural identification of β- and γ-human atrial natriuretic polypeptides
TLDR
The purification and sequence analysis of two novel hANPs of higher Mr, β- and γ-hANP, both of which exhibit natriuretic and hypotensive activity are reported, revealing that the largest form of hANP is processed directly from a 151-residue precursor9 by removal of a 26-Residue signal peptide.
Atrial natriuretic factor: a hormone produced by the heart
TLDR
This hormone, described in 1981 as atrial natriuretic factor (ANF), is diuretic, hypotensive, and has an inhibitory effect on renin and aldosterone secretion.
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TLDR
It appears that atria possess at least two peptides that elicit smooth muscle relaxation and natriuresis, suggesting an endogenous system of fluid volume regulation.
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