A new mutation of E-cadherin gene in familial gastric linitis plastica cancer with extra-digestive dissemination.

Abstract

Over a 12-month period, we diagnosed poorly differentiated infiltrative independent-cell gastric adenocarcinoma in two brothers and one sister aged 41 to 47 years. Their father had died from antral cancer at the age of 34 years. These cancers had two characteristic clinical features: rapid course and distant malignant dissemination. In all three patients… (More)

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