A new mouse mutant for the LDL receptor identified using ENU mutagenesis.

@article{Svenson2008ANM,
  title={A new mouse mutant for the LDL receptor identified using ENU mutagenesis.},
  author={Karen L Svenson and Nadav Ahituv and Rebecca S. Durgin and H. F. J. Savage and Phyllis A. Magnani and Oded Foreman and Beverly J. Paigen and Luanne Laurel Peters},
  journal={Journal of lipid research},
  year={2008},
  volume={49 11},
  pages={2452-62}
}
In an effort to discover new mouse models of cardiovascular disease using N-ethyl-N-nitrosourea (ENU) mutagenesis followed by high-throughput phenotyping, we have identified a new mouse mutation, C699Y, in the LDL receptor (Ldlr), named wicked high cholesterol (WHC). When WHC was compared with the widely used Ldlr knockout (KO) mouse, notable phenotypic differences between strains were observed, such as accelerated atherosclerotic lesion formation and reduced hepatosteatosis in the ENU mutant… CONTINUE READING
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