A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload.

@article{Pigeon2001ANM,
  title={A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload.},
  author={Christelle Haziza Pigeon and Gennady P Ilyin and Brice Courselaud and Patricia Leroyer and Bruno Turlin and Pierre Brissot and Olivier Lor{\'e}al},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 11},
  pages={7811-9}
}
Considering that the development of hepatic lesions related to iron overload diseases might be a result of abnormally expressed hepatic genes, we searched for new genes up-regulated under the condition of iron excess. By suppressive subtractive hybridization performed between livers from carbonyl iron-overloaded and control mice, we isolated a 225-base pair cDNA. By Northern blot analysis, the corresponding mRNA was confirmed to be overexpressed in livers of experimentally (carbonyl iron and… CONTINUE READING
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