A new molecular risk pathway for postpartum mood disorders: clues from steroid sulfatase–deficient individuals

  title={A new molecular risk pathway for postpartum mood disorders: clues from steroid sulfatase–deficient individuals},
  author={Harish Thippeswamy and William Davies},
  journal={Archives of Women's Mental Health},
  pages={391 - 401}
Postpartum mood disorders develop shortly after childbirth in a significant proportion of women. These conditions are associated with a range of symptoms including abnormally high or low mood, irritability, cognitive disorganisation, disrupted sleep, hallucinations/delusions, and occasionally suicidal or infanticidal ideation; if not treated promptly, they can substantially impact upon the mother’s health, mother-infant bonding, and family dynamics. The biological precipitants of such disorders… 

Immune System Alterations and Postpartum Mental Illness: Evidence From Basic and Clinical Research

Evidence from both clinical and animal models suggesting an immune component to post partum depression, postpartum anxiety, and postpartums psychosis is reviewed.

Investigation of hormone levels in postpartum psychosis

  • M. Işık
  • Medicine
    Dusunen Adam:The Journal of Psychiatry and Neurological Sciences
  • 2022
A condition that develops impaired thyroid functions secondary to acute psychotic episode rather than an underlying thyroid disease is suggested, and changes in the hormone profile according to breastfeeding status suggest that the effects of breastfeeding on hormones may also be important.

Transcriptomic Studies of Antidepressant Action in Rodent Models of Depression: A First Meta-Analysis

A meta-analysis of the AD signature of fluoxetine in the hippocampus, the most studied target, and identifies both old players of AD action and novel transcriptional biomarker candidates that warrant further investigation are performed.

The Impact of ACEs on BMI: An Investigation of the Genotype-Environment Effects of BMI

The study found very strong significant associations between the number of adverse childhood experiences and adult obesity and the delicate balance between genes and environment, and how the two strongly influence each other.

University of Birmingham Steroid sulphatase and its inhibitors

  • Biology, Medicine
  • 2021
There is now good evidence to suggest they may also provide benefits in patients with colorectal and ovarian cancer, and in treating endometriosis, and the further development of potent STS inhibitors will allow their potential therapeutic value to be explored in a variety of hormone ‐ dependent cancers and possibly other non-oncological conditions.

Steroid Sulphatase and Its Inhibitors: Past, Present, and Future

A look back at the work on STS inhibitors and their contribution to the understanding of sulphate biology and as potential therapeutic agents in hormone-dependent disease is taken.

TRPM3 in Brain (Patho)Physiology

The available data regarding the roles of TRPM3 in the brain are summarized, and these data are correlated with the neuropathological processes in which this ion channel may be involved.



An Analysis of Cellular Communication Network Factor Proteins as Candidate Mediators of Postpartum Psychosis Risk

  • W. Davies
  • Psychology, Biology
    Front. Psychiatry
  • 2019
It is argued, on the basis of multiple lines of new evidence, that altered expression of the Cellular Communication Network (CCN) factor proteins (and of the heterodimerizing CCN2 and CCN3 proteins in particular), may be associated with, and possibly causal for, increased PP risk.

Does steroid sulfatase deficiency influence postpartum psychosis risk?

  • W. Davies
  • Psychology, Medicine
    Trends in molecular medicine
  • 2012

Postpartum Psychosis: Madness, Mania, and Melancholia in Motherhood.

Postpartum psychosis offers an intriguing model to explore etiologic contributions to the neurobiology of affective psychosis and strategies for prevention include lithium prophylaxis immediately postpartum and proactive safety monitoring.

Do Defective Immune System-Mediated Myelination Processes Increase Postpartum Psychosis Risk?

Cognitive, behavioural and psychiatric phenotypes associated with steroid sulfatase deficiency

Evidence from human and animal model studies suggesting that STS deficiency might predispose to neurobehavioural abnormalities and certain psychiatric disorders are discussed and potential mechanisms that may underlie these vulnerabilities are discussed.

Immune System Dysregulation in First-Onset Postpartum Psychosis

TDAG51 is a crucial regulator of maternal care and depressive-like behavior after parturition

TDAG51 is a maternal care-associated gene that functions as a crucial regulator of maternal and depressive-like behavior after parturition, which indicates that TDAG51 plays a protective role against maternal care defects and depressive -like behavior in stress-sensitive women.

Postpartum psychiatric disorders

Treating postpartum mental illness are reducing maternal symptoms and supporting maternal–child and family functioning and developing effective strategies in global settings that allow the delivery of targeted therapies to women with different clinical phenotypes and severities of PPDs is essential.

Prevalence of autoimmune thyroid dysfunction in postpartum psychosis

Women with postpartum psychosis are at higher risk not only of AITD but also of clinical thyroid failure, and screening for thyroperoxidase antibodies is warranted in patients with post partum psychosis.

Stratification of the risk of bipolar disorder recurrences in pregnancy and postpartum

Preinatal history of affective psychosis or depression is the most important predictor of perinatal recurrence in women with bipolar disorder and can be used to individualise risk assessments.